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KMID : 1202020110040010054
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Journal of Korean Thyroid Association
2011 Volume.4 No. 1 p.54 ~ p.57
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A Case of Agranulocytosis and Soft Tissue Abscess after Increasing Methimazole Dose in a Patient with Graves Disease under Long-term Mainternance Therapy
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Park Se-Yoon
Chun Sung-Wan
Kim Yeo-Joo
Kim Sang-Jin
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Abstract
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Antithyroid drugs (ATD) has been widely used to treat Graves’ disease. However agranulocytosis, a serious fatal complication of ATD treatment, occurs in about 0.5 percent. The symptoms may mimic viral infections (fever, sore throat), and the potentially life-threatening pyogenic infections can go unrecognized initially. The median duration of drug exposure before the onset of acute agranulocytosis is within 30 days in most cases. We report a case of agranulocytosis with secondary soft tissue infection and abscess occuring after increasing the dose of methimazole in a woman who had taken methimazole for more than 10 years. We administered broad-spectrum antibiotics and aspirated the soft tissue abscess. A review of the medical literature regarding agranulocytosis in the setting of ATDs is presented.
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KEYWORD
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Agranulocytosis, Graves’ disease, Soft tissue infections
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